-Doses greater than 20 mg/day have not been studied in this patient population. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. -An initial dose of 40 mg may be used in patients who require a larger reduction in low density lipoprotein (e.g. 5. 10 years or older: 10 mg to 80 mg orally once a day -Take orally once a day at any time, with or without food Monitoring: Children 10 to 17 years of age—At first, 10 mg once a day. Take this medicine only as directed by your doctor. Patients who require a large reduction in LDL-C (more than 45%) may be started at 40 mg once daily. Computer 'Nudge' Spurs Doctors to Prescribe Statins to Heart Patients, Statins Going Generic Saved Medicare Billions. -As an adjunct to diet to reduced total cholesterol (total-C), LDL-C, apolipoprotein B (apo B), and triglyceride (TG) levels, and to increase high density lipoprotein (HDL-C) in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson Types IIa and IIb). more than 45%) Comments: However, the dose is usually not more than 20 mg per day. -Counsel patients on the importance of contraceptive methods while taking this drug. Do not break, crush, or chew it. -As an adjunct to diet for the treatment of patients with elevated TG levels (Fredrickson Type IV). Take this medicine at the same time each day. Keep from freezing. Drinking large amounts of grapefruit juice (more than 1.2 liters each day) while you take this medicine may increase your risk of muscle injury and could result in kidney problems. -Patients should be aware that there are a number of potential drug interactions with this drug and they should speak with a healthcare professional before starting any new medications including over the counter medications. -Patients should be instructed to read the US FDA-approved patient labeling (Patient Information). Take this medicine with or without food. -Pregnancy The best time to take statins depends on the specific drug. LIMIT atorvastatin dose to 40 mg/day with concomitant use of nelfinavir; appropriate clinical assessment is recommended to ensure the lowest effective dose is employed. AVOID concomitant atorvastatin use with cyclosporine, tipranavir plus ritonavir, glecaprevir plus pibrentasvir If you miss a dose of this medicine, take it as soon as possible. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. The amount of medicine that you take depends on the strength of the medicine. Active liver disease (including unexplained persistent elevations in hepatic transaminase levels): Contraindicated, Elderly: Use caution as patients 65 years or older are at risk for myopathy We comply with the HONcode standard for trustworthy health information -, Hyperlipoproteinemia Type IIa (Elevated LDL), Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL), Hyperlipoproteinemia Type III (Elevated beta-VLDL + IDL), Hyperlipoproteinemia Type IV (Elevated VLDL), Heterozygous Familial Hypercholesterolemia. General: Adults—At first, 10 or 20 milligrams (mg) once a day. -Hypersensitivity to the active substance or any of the product ingredients -Lactation Available for Android and iOS devices. Mayo Clinic does not endorse companies or products. Side effects. Your doctor will do blood tests to tell how well this dose is working for you and may gradually increase the dose … However, the dose is usually not more than 80 mg per day. Copyright © 2020 IBM Watson Health. -This drug has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson Types I and V). Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Do not keep outdated medicine or medicine no longer needed. If your dose is different, do not change it unless your doctor tells you to do so. -Individualize dose based on goals of therapy and response This content does not have an Arabic version. CONTRAINDICATIONS: Initial dose: 10 mg orally once a day -Following initiation and/or upon titration, lipid levels should be evaluated within 2 to 4 weeks and dosages adjusted accordingly. The dosage range of LIPITOR is 10 to 80 mg once daily. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Talk to your pharmacist or doctor if you're worried or take more than 1 extra dose. 10 mg to 80 mg orally once a day -Metabolic: Obtain lipid levels within 2 to 4 weeks of initiating therapy and adjusting dose; periodically test during therapy to determine goal attainment This content does not have an English version. Use: For the prevention of cardiovascular disease. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Maintenance dose: 10 mg to 80 mg orally once a day However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Comments: -Following initiation and/or upon titration, lipid levels should be evaluated within 2 to 4 weeks and dosages adjusted accordingly. Children younger than 10 years of age)—Use and dose must be determined by your doctor. -Individualize dose based on goals of therapy and response -Advise patients to report immediately any unexplained muscle pain, tenderness, or weakness, especially if accompanied by malaise or fever, or if muscle signs/symptoms persist after discontinuing therapy. LIPITOR can be administered as a single dose at any time of the day, with or without food. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. -For the treatment of patients with primary dysbetalipoproteinemia (Fredrickson Type III) who do not respond adequately to diet. Use: As an adjunct to diet to reduce total-C, LDL-C, and apo B levels in pediatric patients 10 years or older with heterozygous familial hypercholesterolemia. 10 years or older: Hemodialysis is not expected to significantly enhance atorvastatin clearance since this drug is extensively bound to plasma proteins © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). -Musculoskeletal: Monitor for skeletal muscle effects -In patients with type 2 diabetes and multiple risk factors for CHD such as retinopathy, albuminuria, smoking, or hypertension, this drug is indicated to reduce the risk of: Myocardial infarction and stroke. Initial dose: 10 mg or 20 mg orally once a day. Atorvastatin (Lipitor) and simvastatin (Zocor) are both statins that lower cholesterol levels in the bloodstream. Maximum dose: 80 mg/day -This drug has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson Types I and V). -In patients with clinically evident CHD, this drug is indicated to reduce the risk of/for: Non-fatal myocardial infarction, fatal and non-fatal stroke, revascularization procedures, hospitalization for CHF, and angina. Administration advice: Advertising revenue supports our not-for-profit mission. Taking an extra dose of atorvastatin by accident is unlikely to harm you. Use: To reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid lowering treatment (e.g., LDL apheresis) or if such treatments are unavailable. more than 45%) Select one or more newsletters to continue. Dosage for dyslipidemia (cholesterol problems) Adult dosage (ages 18–64 years) Child dosage (ages 10–17 years) Senior dosage (ages 65 years and older) Peritoneal dialysis: Data not available. -Individualize dose based on goals of therapy and response Your doctor may increase your dose as needed. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Is Repatha (evolocumab) effective without a statin. Initial dose: 10 mg or 20 mg orally once a day Safety and efficacy have not been established in patients younger than 10 years with HeFH (heterozygous familial hypercholesterolemia) or pre-pubertal adolescents. Concomitant lipid lowering therapy: Some patients may need to start at 40 mg per day. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. The dose of this medicine will be different for different patients. -Hepatic: Check transaminase levels prior to initiating therapy; repeat, if signs/symptoms of liver injury occur, and as clinically indicated throughout therapy Applies to the following strengths: 10 mg; 20 mg; 40 mg; 80 mg. Some statins work best in the evening while others work just as well in the morning. Ask your healthcare professional how you should dispose of any medicine you do not use. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. These drugs, part of a family called statins, are prescribed to treat a large number of cardiovascular disease, including to prevent heart failure. -An initial dose of 40 mg may be used in patients who require a larger reduction in low density lipoprotein (e.g. Do not use more of it, do not use it more often, and do not use it or for a longer time than your doctor ordered. This could cause unwanted effects on the liver. -Clinical efficacy with dosages up to 80 mg/day for 1 year was evaluated in an uncontrolled study of patients with homozygous familial hypercholesterolemia (HoFH); this study included 8 pediatric patients. -Individualize dose based on goals of therapy and response atorvastatin stay in the morning doctor orders! Computer 'Nudge ' Spurs Doctors to Prescribe statins to heart patients, Going... The same time each day chew it than 10 years of age—At first, 10 or mg! Stopping the drug linked below rosuvastatin, LIPITOR, Crestor, pravastatin evolocumab. Taking this drug the amount of medicine that you take depends on the strength of the day, or. Patients may need to start at 40 mg once daily and pregnancy safety information before taking this drug is bound... And Research ( MFMER ) dose: 10 mg or 20 milligrams ( mg ) once a day -as adjunct! Should be made at intervals of 4 weeks or more our safe care and visitor,... 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