You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. Examples of these other drugs include: You may wonder how Repatha compares with other medications that are prescribed for similar uses. However, kidney or liver side effects can occur with statin drugs. After a single administration, Repatha reaches its median peak serum concentration after 3 to 4 days. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Repatha and Crestor to treat. heart attack, stroke, death from cardiovascular disease, hospitalization for unstable angina and certain types of heart surgery occurred at a rate of 5.2 per 100 patient years in people who received the placebo. Statins lower cholesterol by preventing your liver from making new cholesterol. FDA Approved: Yes (First approved August 27, 2015) Brand name: Repatha Generic name: evolocumab Dosage form: Injection Company: Amgen Inc. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency. To find current prices for Repatha in your area, check out GoodRx.com. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes. Usual Adult Dose of Repatha for Hyperlipidemia: -140 mg subcutaneously every 2 weeks, or Then go back to your original dosing schedule. high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor. Examples of drugs that may be used with Repatha to treat high cholesterol include ezetimibe (Zetia), and statins such as Lipitor or Crestor. Crestor comes as a tablet that you take by mouth. Repatha is used in people with HoFH who’ve tried lowering their LDL cholesterol with diet and other treatments but still need help lowering their cholesterol. The 420 mg/3.5 mL strength is only available in the cartridges used with the Pushtronex system. It may also be used with other drugs that lower your cholesterol, such as a statin. This enzyme, called PCSK9, is found in your liver. There are two ways your child can receive their dose: Below are answers to some questions you may have about taking Repatha. Before using Repatha, take the drug out of the refrigerator and allow it to warm to room temperature (68°F to 77°F/20°C to 25°C). Cholesterol can also be found in foods such as eggs, cheese, and meat. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. These conditions can cause high blood levels of LDL cholesterol, and can also cause plaque to build up inside your arteries. Evolocumab is not approved for use by anyone younger than 13 years old. In clinical studies, people taking Repatha didn’t have liver side effects, including changes in their levels of liver enzymes. Regulators approved a new type of cholesterol-lowering drug aimed at millions of people who can't tolerate statins. However, weight loss can be caused by gastroenteritis, which was a side effect seen in studies of Repatha. Your doctor will prescribe either a 140-mg dose of Repatha every 2 weeks or a 420-mg dose once every month. Generic Name: evolocumab (E voe LOK ue mab) They found that: Repatha is FDA-approved for use in children ages 13 to 17 years with homozygous familial hypercholesterolemia (HoFH). This can include setting an alarm on your phone or downloading a reminder app. A biosimilar is very similar version of the parent biologic drug, but it’s not identical. Instead, use a new Repatha dose. People taking the drug or caregivers may be trained on preparing and injecting Repatha at home. Last medically reviewed on September 27, 2020, Eating a healthful diet is one way to keep cholesterol levels in check. Instructions on how to inject Repatha using Repatha prefilled syringe, Repatha SureClik Autoinjector, and the Pushtronex system (Repatha on-body infusor) for Repatha. The generic is considered to be as safe and effective as the original drug. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional, Repatha expiration, storage, and disposal, Tuberculosis vaccine may help protect against COVID-19, Jaw-clenching and teeth-grinding during the pandemic, The impact of historical trauma on American Indian health equity, The Recovery Room: News beyond the pandemic — November 27. Cholesterol itself isn’t a harmful substance. Your insurance company may require you to use a specialty pharmacy to get Repatha. If you experience symptoms of diabetes, talk with your doctor. They’re considered to be as safe and effective as the parent drug. In a clinical study, Repatha was effective at reducing the risk of heart attack or stroke in adults with heart disease. Repatha ® helps the liver clear LDL bad cholesterol by limiting the actions of a protein called PCSK9—and less PCSK9 means less LDL in your blood. A 12-week clinical study comparing Repatha with a placebo found Repatha to be effective for lowering LDL cholesterol levels in adults and children with HoFH. Repatha is usually given once a month, or once every 2 weeks. Both Repatha and Crestor are FDA-approved to: treat high cholesterol caused by homozygous familial, primary dysbetalipoproteinemia (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), heterozygous familial hypercholesterolemia (HeFH) in children ages 8 to 17 years, Pushtronex system, which is a single-use, on-body infusor with prefilled cartridges, treat primary hyperlipidemia (high cholesterol) in adults, when used with a healthy diet, treat high cholesterol caused by homozygous familial hypercholesterolemia (HoFH) in adults and children, when used with a healthy diet, reduce the risk of cardiovascular problems (such as heart attack and stroke) in adults, people who received 140 mg of Repatha every 2 weeks with a statin had their LDL levels lowered by 63%, people who received a placebo every 2 weeks had their LDL levels increased by 8%, people who received 420 mg of Repatha once a month had their LDL levels reduced by 59%, people who received a placebo once a month had their LDL levels increased by 4%, procedures that help restore blood flow to the heart. 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