When the inspired oxygen saturation or FiO2 of a patient on oxygen therapy is kept for long time Toxicity of oxygen is bound can take place.FiO2 of 100 % should not be kept for more than 12 hours. 2. Oxygen toxicity can be minimized by keeping the P A O 2 less than 80 mm Hg or the FIO 2 below 0.40 to 0.50 . Oxygen Toxicity occurs when excessive oxygen inhalation is done as in prolonged ventilation with hundred percent (100%) oxygen.. The pulmonary cellular response to hyperoxic exposure and increased ROS is well described. If a patient receives an FiO2 > 60% for a prolonged period of time, it increases their chances of oxygen toxicity. Air pressure changes within the enclosed lung cavity and ventilator-induced injury may accompany and be indistinguishable from O 2 toxicity. If the FiO2 is high, then O2 saturation will remain high as the CO2 rises. It might be due to oxygen toxicity. The biochemical basis of oxygen toxicity is increased production of highly reactive, partially reduced metabolites of oxygen, including hydrogen peroxide and free radicals, by cells in hyperoxia. In its simplest form, a modern positive pressure ventilator consists of a compressible air reservoir or turbine, air and oxygen supplies, a set of valves and tubes, and a disposable or reusable "patient circuit". Oxygen toxicity is an iatrogenic illness caused by a high partial pressure of inspired oxygen during the course of oxygen therapy. Oxygen is toxic because of its propensity to undergo univalent reduction leading to the generation of reactive oxygen … However, another area of controversy that actually predates the concept of ventilator-induced lung injury is pulmonary oxygen toxicity. oxygen toxicity (too much oxygen in the lungs) Other ventilator risks include: skin infections; ... respiratory rate (breathing) oxygen saturation; You may also need a chest X-ray or scan. Appropriate use of oxygen aims to provide a balance between the two effects. If this gas is inhaled in concentrated form, it can be toxic to human and may lead to several symptoms [1, 2]. Oxygen toxicity refers to inflammatory changes, alveolar infiltration, and, eventually, pulmonary fibrosis that can develop following prolonged exposure to high FIO2 (eg, > 0.6). Flow Rate The inspiratory flow rate is a rate that controls how fast a tidal volume is delivered by the ventilator. Oxygen may be essential to life but it must be received in a certain concentration to achieve the desired biological benefit. Although local oxygen toxicity to the lung is well accepted, recent evidence has called into question the negative consequences of hyperoxemia in other organ beds. Oxygen is both lifesaving and toxic. Much less has been written about this topic recently than about alveolar overdistension and mechanical lung injury from high pressures and sheer forces. 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