Backes JM, Venero CV, Gibson CA, et al. [16] The doses of rosuvastatin used in our study were 2.5, 5, or 10 mg EOD (mean 5.6 mg). Dosing a statin (rosuvastatin) every other day (EOD) may provide significant lipoprotein changes while avoiding common adverse effects in this statin-intolerant population. Statin-related myalgias and hepatotoxicity are dose-related and so reducing systemic drug concentration may lower the incidence of ADRs and potentially increase adherence to the regimen. © 2008  Harvey Whitney Books Company. 2005;8:197-199. Ischemic Stroke May Hint at Underlying Cancer, Topol: US Betrays Healthcare Workers in Coronavirus Disaster, The 6 Dietary Tips Patients Need to Hear From Their Clinicians, Type of previous statin intolerance, n (%), Previous number of intolerable statins, n (%), Previous intolerances to individual statins, n. One proposed mechanism of improving statin tolerance is alternate day statin therapy;12, 13, 14 but so far no specific management goals and treatment plans exist for South Asians because of lack of data. Maintenance of low-density lipoprotein goal with step-down pravastatin therapy. Every-other-day dosing, especially of statins with longer half-lives is shown to preserve lipid-lowering benefits. Ann Pharmacother. Possible explanations include the positive psychological effect of EOD treatment or lower plasma and muscle concentrations. 2010;44:1459-1470.3. Zhang H, Plutzky J, Skentzos, et al. 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[16] Also, lovastatin, simvastatin, and atorvastatin are largely metabolized by CYP3A4, which is responsible for the conversion of many lipid-soluble agents to their hydrophilic forms for clearance and is a primary isoenzyme involved in many common drug interactions. Ann intern Med. The 80% rate of tolerance in that investigation is similar to what we observed (72.5%; 37/51) in the present study. Our findings are similar to previous data from case reports and small trials. You've successfully added to your alerts. Recently, a significant 39% reduction in LDL-C was achieved with rosuvastatin (10 mg) EOD among patients without a previous statin intolerance. This website also contains material copyrighted by 3rd parties. Reindl E, Wright BM, Wargo KA. HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; TC = total cholesterol; TG = triglycerides. Click the topic below to receive emails when new articles are available. 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